García-Martínez, P., D. López Aventín, S. Segura, I. Gómez-Martín, J. Lloreta, J. Ibáñez, J. J. Elvira, and R. M. Pujol (2016), In vivo reflectance confocal microscopy characterization of silver deposits in localized cutaneous argyria, British Journal of Dermatology, 175(5), 1052-1055, doi: 10.1111/bjd.14571.


Localized cutaneous argyria is a rare condition secondary to skin deposition of silver following exposure to substances containing this metal. The clinical appearance and dermoscopy findings require deep melanocytic lesions and particularly melanoma metastasis to be ruled out. Silver deposits are usually confirmed by scanning electron microscopy and/or energy-dispersive X-ray spectroscopy. Herein we describe the in vivo reflectance confocal microscopy (RCM) features observed in one case of localized cutaneous argyria. These features include the presence of a hyperrefractile network in the papillary dermis and a periadnexal dotted bright pattern. In vivo RCM might be a useful tool for an early diagnosis of this uncommon entity.

Reference paper

We use cookies to improve our website and your experience when using it. Cookies used for the essential operation of this site have already been set. To find out more about the cookies we use and how to delete them, see our privacy policy.

  I accept cookies from this site.
EU Cookie Directive plugin by