Educational Background

  • 2003. Ph D. in Biology. Complutense University of Madrid.a
  • 1997. Degree in Biology. Complutense University of Madrid


Research Interests


Active Projects



Previous selected publications


Álvarez M, Nevot M, Mendieta J, Martínez MA, Menéndez-Arias L. Amino acid residues in HIV-2 reverse transcriptase that restrict the development of nucleoside analogue resistance through the excision pathway. J. Biol. Chem. (2018). 293(7):2247-2259


Álvarez M, Sebastián-Martín A, García-Marquina G, Menéndez-Arias L. Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases. Sci. Rep. (2017) Mar 23,7:44834 doi:10.1038/srep 44834


Menéndez-Arias L, Sebastián-Martín A, Álvarez M. Viral reverse transcriptases. Virus Res. (2016). Dec 30 doi: 10.1016/ j.virusres 2016.12019


Betancor G, Álvarez M, Marcelli B, Andrés C, Martínez MA, Menéndez-Arias L. Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis. Nucleic Acids Res. (2015) 43(4): 2259-2270


Pauls, E., Ruiz, A., Badia, R., Permanyer, M., Gubern, A., Riveira-Muñoz, E., Torres-Torrenteras, J., Alvarez, M., Mothe, B., Brander, C., Crespo, M., Menéndez-Arias, L., Clotet, B., Keppler, OT., Marti, R., Posas, F., Ballana, E., Esté, JA. Cell cycle control and HIV-1 susceptability are linked by CDK6-dependent CDK2 phosphoriylation of SAMHD1 in myeloid and lymphoid cells. J. Immunol. (2014) 193: 1988-1997

Menéndez-Arias, L., Álvarez, M., Pacheco, B. Nucleside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance. Curr Opin Virol. (2014) 8: 1-9

Menéndez-Arias, L., Alvarez, M. Antiretroviral therapy and drug resistance in human immunodeficiency virus type 2 infection. Antiviral Res. (2014) 102: 70-86

Álvarez, M., Menéndez-Arias, L. Temperature effects on the fidelity of a thermostable HIV-1 reverse transcriptase. FEBS J. (2014) 281(1): 342-351


Álvarez, M., Barrioluengo, V., Afonso-Lehmann, RN., Menéndez-Arias, L. Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis. Nucleic Acids Res. (2013) 41(8): 4601-4612


Barrioluengo, V., Alvarez, M., Barbieri, D., Menéndez-Arias, L. Thermostable HIV-1 group O reverse transcriptase variants with the same fidelity as murine leukaemia virus reverse transcriptase. Biochem J. (2011) 436(3): 599-607


Sanz, C., Vazquez ,P., Blazquez, C., Barrio, P., Alvarez, MD., Blazquez, E. Signalling and biological effects of glucagon-like peptide 1 (glp-1) on the differentiation of mesenchymal stem cells from human bone marrow. Am J Physiol Endocrinol Metab.( 2010) 298 : E634-E643


Alvarez, M., Matamoros, T., Menéndez-Arias, L. Increased thermostability and fidelity of DNA synthesis of wild-type and mutant HIV-1 group O reverse transcriptases. J Mol Biol. (2009) 392(4): 872-84


Asúa, T., Bilbao, A., Gorriti, MA., Lopez-Moreno, JA., Del Mar Alvarez, M., Navarro, M., Rodríguez de Fonseca, F., Perez-Castillo, A., Santos, A. Implication of the endocannabinoid system in the locomotor hyperactivity associated with congenital hypothyroidism. Endocrinology (2008) 149(5): 2657-2666

Menéndez-Arias, L., Matamoros, T., Álvarez, M. Ritonavir-boosted darunavir: a powerful option for treatment-experienced HIV-1-infected patients. Future Virol. (2008).3(5)


Santos, A., Del Mar Alvarez, M., Mauro, MS., Abrusci, C., Marquina, D. The transcriptional response of Saccharomyces cerevisiae to Pichia membranifaciens killer toxin.J. Biol Chem. (2005). 280(51): 41881-92.

Álvarez, M., Pérez-Castillo, A., Santos, A. Thyroid hormone regulates Galphai1 gene expression in the rat cerebellar cortex during postnatal development. J Neurochem. (2005) 92(2): 395-404.

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